Gout is a metabolic disorder that causes joint inflammation. It can arise when a combination of dietary, medical, or genetic factors causes excess uric acid to build up inside the body. Sharp crystals of urate salts then form in the bloodstream and deposit in the joint tissues. Acute attacks are usually painful, with extreme tenderness, redness, and swelling. The big toe is the most common location, but gout can also afflict other joints. Attacks may recur after months or years. They can be treated or lessened with anti-inflammatory medications and dietary adjustments. Without treatment, other complications may result.
Clusters of urate crystals called tophi can form under the skin and joint tissues can be permanently damaged.
This illustration, plus dozens of 3D models and animations, can be found in our brand new app Physiology & Pathology, available now! Link in bio. - 6 minutes ago