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#Scientists have tried to develop synthetic red blood cells that mimic the favorable properties of natural ones, such as flexibility, oxygen transport and long circulation times. Now, researchers have made synthetic red blood cells that have all of the cells' natural abilities, plus a few new ones.
The researchers made the synthetic cells by first coating donated human #RBCs with a thin layer of #silica . They layered positively and negatively charged polymers over the silica-RBCs, and then etched away the silica, producing flexible replicas. Finally, the team coated the surface of the replicas with natural RBC membranes. The artificial cells were similar in size, shape, charge and surface #proteins to natural cells, and they could squeeze through model capillaries without losing their shape. .
*Journal Reference* : Jimin Guo, Jacob Ongudi Agola, Rita Serda, Stefan Franco, Qi Lei, Lu Wang, Joshua Minster, Jonas G. Croissant, Kimberly S. Butler, Wei Zhu, C. Jeffrey Brinker. Biomimetic Rebuilding of Multifunctional Red Blood Cells: Modular Design Using Functional Components. ACS Nano, 2020; DOI: 10.1021/acsnano.9b08714
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